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Meh, not really...3DS would have some cool effects but I don't really care much.
Its a good concept though since the game doesn't require a second method of movement for the camera.
Here's a better idea:
Metroid. F-Zero. Wave Race. 1080° Snowboarding. Donkey Kong. Star Fox. Mach Rider Unchained. Maybe a new Wario platformer. New IP.
For a second 3D Mario platformer, let's go to new territories, please. Nintendo is being too safe lately, let's end the trend.